From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events: JACC State-of-the-Art Review
It has been believed that most acute coronary events result from the rupture of mildly stenotic
plaques, based on studies in which angiographic information was available from many …
plaques, based on studies in which angiographic information was available from many …
Coronary atherosclerotic vulnerable plaque: current perspectives
C Stefanadis, CK Antoniou, D Tsiachris… - Journal of the American …, 2017 - Am Heart Assoc
Atherosclerosis is the most common form of vascular disease and constitutes the major
cause of death, with 17.5 million related deaths annually (31% of global mortality). 1 …
cause of death, with 17.5 million related deaths annually (31% of global mortality). 1 …
Arterial thrombosis—insidious, unpredictable and deadly
SP Jackson - Nature medicine, 2011 - nature.com
The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …
Inflammation and atherosclerosis
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …
ongoing inflammatory response. Recent advances in basic science have established a …
Pathophysiology of coronary artery disease
P Libby, P Theroux - Circulation, 2005 - Am Heart Assoc
During the past decade, our understanding of the pathophysiology of coronary artery
disease (CAD) has undergone a remarkable evolution. We review here how these advances …
disease (CAD) has undergone a remarkable evolution. We review here how these advances …
The myth of the “vulnerable plaque” transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment
A Arbab-Zadeh, V Fuster - Journal of the American College of Cardiology, 2015 - jacc.org
The cardiovascular science community has pursued the quest to identify vulnerable
atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events …
atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events …
Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime
D Steinberg - Nature medicine, 2002 - nature.com
A historical perspective on atherosclerosis allows us to reflect on the once controversial
hypotheses in the field. Plaque formation was once thought to be dependent upon …
hypotheses in the field. Plaque formation was once thought to be dependent upon …
Do plaques rapidly progress prior to myocardial infarction? The interplay between plaque vulnerability and progression
There is a common misperception in the cardiology community that most acute coronary
events arise from ruptures of mildly stenotic plaques. This notion has emanated from …
events arise from ruptures of mildly stenotic plaques. This notion has emanated from …
Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
E Westein, AD van der Meer… - Proceedings of the …, 2013 - National Acad Sciences
Rupture of a vulnerable atherosclerotic plaque causes thrombus formation and precipitates
cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the …
cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the …
Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease
G Pasterkamp, HM Den Ruijter, P Libby - Nature Reviews Cardiology, 2017 - nature.com
The concept of the'vulnerable plaque'originated from pathological observations in patients
who died from acute coronary syndrome. This recognition spawned a generation of research …
who died from acute coronary syndrome. This recognition spawned a generation of research …