Antibiotic resistant bacterial infections are now a leading cause of global mortality. While
drug resistance continues to spread, the clinical antibiotic pipeline has become bare. This …

The rapid development and spread of antibiotic resistance necessitate the development of
novel strategies for antibiotic discovery. Symbah-1, a synthetic peptide antibiotic, was …

The lack of available treatments for many antimicrobial-resistant infections highlights the
critical need for antibiotic discovery innovation. Peptides are an underappreciated antibiotic …

Peptide macrocycles are a rapidly emerging class of therapeutic, yet the design of their
structure and activity remains challenging. This is especially true for those with β-hairpin …

Phage-derived peptidoglycan hydrolases (ie, lysins) are considered a promising alternative
to traditional antibiotics due to their low risks of resistance and unique mechanisms of action …

Peptide macrocycles are a rapidly emerging new class of therapeutic, yet the design of their
structure and activity remains challenging. This is especially true for those with β-hairpin …