The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by
multiple features consistent with accelerated aging. It is caused by null mutations of the …

Recognition and repair of damaged replication forks are essential to maintain genome
stability and are coordinated by the combined action of the Fanconi anemia and …

Inhibitors of poly (ADP-ribose) polymerase (PARP) have demonstrated efficacy in women
with BRCA-mutant ovarian cancer. However, only 15%–20% of ovarian cancers harbor …

Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid
unwinding. The growing number of DNA helicases implicated in human disease suggests …

Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated
in the maintenance of genome stability. The conserved RecQ family also includes RecQ1 …

Prevention and repair of DNA damage is essential for maintenance of genomic stability and
cell survival. DNA replication during S-phase can be a source of DNA damage if …

Since the original observations made in James German's Laboratory that Bloom's syndrome
cells lacking BLM exhibit a decreased rate of both DNA chain elongation and maturation of …

Human genetic diseases that resemble accelerated aging provide useful models for
gerontologists. They combine known single-gene mutations with deficits in selected tissues …

Genomic instability is a hallmark of cancer and aging. Premature aging (progeroid)
syndromes are often caused by mutations in genes whose function is to ensure genomic …