Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus
S Khosla, P Samakkarnthai, DG Monroe… - Nature Reviews …, 2021 - nature.com
Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …
patients sustain fractures despite having higher levels of areal bone mineral density, as …
[HTML][HTML] Accelerated AGEing: The impact of advanced glycation end products on the prognosis of chronic kidney disease
E Dozio, L Caldiroli, P Molinari, G Castellano… - Antioxidants, 2023 - mdpi.com
Advanced glycation end products (AGEs) are aging products. In chronic kidney disease
(CKD), AGEs accumulate due to the increased production, reduced excretion, and the …
(CKD), AGEs accumulate due to the increased production, reduced excretion, and the …
Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study
AV Schwartz, JYC Backlund, IH de Boer… - The Lancet Diabetes & …, 2022 - thelancet.com
Background Type 1 diabetes is associated with lower bone mineral density (BMD) and
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …
[HTML][HTML] Sarcopenia in chronic kidney disease: Focus on advanced glycation end products as mediators and markers of oxidative stress
Sarcopenia is common in chronic kidney disease (CKD), and it is independently associated
with morbidity and mortality. Advanced glycation end products (AGE) are mainly known as …
with morbidity and mortality. Advanced glycation end products (AGE) are mainly known as …
[HTML][HTML] The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
NL Reynaert, LEGW Vanfleteren… - Journal of Clinical …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …
[HTML][HTML] Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes
BA Eckhardt, JL Rowsey, BS Thicke, DG Fraser… - JCI insight, 2020 - ncbi.nlm.nih.gov
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher
bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part …
bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part …
[HTML][HTML] Diabetes risk factors and bone microarchitecture as assessed by high-resolution peripheral quantitative computed tomography in adults with long-standing …
N Sinha Gregory, AJ Burghardt, JYC Backlund… - Diabetes …, 2024 - diabetesjournals.org
OBJECTIVE To determine whether type 1 diabetes and its complications are associated with
bone geometry and microarchitecture. RESEARCH DESIGN AND METHODS This cross …
bone geometry and microarchitecture. RESEARCH DESIGN AND METHODS This cross …
[HTML][HTML] Crosstalk between senescent bone cells and the bone tissue microenvironment influences bone fragility during chronological age and in diabetes
T Teissier, V Temkin, RD Pollak, LS Cox - Frontiers in Physiology, 2022 - frontiersin.org
Bone is a complex organ serving roles in skeletal support and movement, and is a source of
blood cells including adaptive and innate immune cells. Structural and functional integrity is …
blood cells including adaptive and innate immune cells. Structural and functional integrity is …
[HTML][HTML] Bisphosphonate treatment ameliorates chemotherapy-induced bone and muscle abnormalities in young mice
Chemotherapy is frequently accompanied by several side effects, including nausea,
diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that …
diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that …
Biochemical markers of bone turnover in older adults with type 1 diabetes
MR Rubin, IH De Boer, JYC Backlund… - The Journal of …, 2022 - academic.oup.com
Abstract Context Type 1 diabetes (T1D) is characterized by high fracture risk, yet little is
known regarding diabetes-related mechanisms or risk factors. Objective Determine whether …
known regarding diabetes-related mechanisms or risk factors. Objective Determine whether …