Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

S Khosla, P Samakkarnthai, DG Monroe… - Nature Reviews …, 2021 - nature.com
Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …

[HTML][HTML] Accelerated AGEing: The impact of advanced glycation end products on the prognosis of chronic kidney disease

E Dozio, L Caldiroli, P Molinari, G Castellano… - Antioxidants, 2023 - mdpi.com
Advanced glycation end products (AGEs) are aging products. In chronic kidney disease
(CKD), AGEs accumulate due to the increased production, reduced excretion, and the …

Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study

AV Schwartz, JYC Backlund, IH de Boer… - The Lancet Diabetes & …, 2022 - thelancet.com
Background Type 1 diabetes is associated with lower bone mineral density (BMD) and
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …

[HTML][HTML] Sarcopenia in chronic kidney disease: Focus on advanced glycation end products as mediators and markers of oxidative stress

E Dozio, S Vettoretti, G Lungarella, P Messa… - Biomedicines, 2021 - mdpi.com
Sarcopenia is common in chronic kidney disease (CKD), and it is independently associated
with morbidity and mortality. Advanced glycation end products (AGE) are mainly known as …

[HTML][HTML] The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD

NL Reynaert, LEGW Vanfleteren… - Journal of Clinical …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …

[HTML][HTML] Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

BA Eckhardt, JL Rowsey, BS Thicke, DG Fraser… - JCI insight, 2020 - ncbi.nlm.nih.gov
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher
bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part …

[HTML][HTML] Diabetes risk factors and bone microarchitecture as assessed by high-resolution peripheral quantitative computed tomography in adults with long-standing …

N Sinha Gregory, AJ Burghardt, JYC Backlund… - Diabetes …, 2024 - diabetesjournals.org
OBJECTIVE To determine whether type 1 diabetes and its complications are associated with
bone geometry and microarchitecture. RESEARCH DESIGN AND METHODS This cross …

[HTML][HTML] Crosstalk between senescent bone cells and the bone tissue microenvironment influences bone fragility during chronological age and in diabetes

T Teissier, V Temkin, RD Pollak, LS Cox - Frontiers in Physiology, 2022 - frontiersin.org
Bone is a complex organ serving roles in skeletal support and movement, and is a source of
blood cells including adaptive and innate immune cells. Structural and functional integrity is …

[HTML][HTML] Bisphosphonate treatment ameliorates chemotherapy-induced bone and muscle abnormalities in young mice

AL Essex, F Pin, JR Huot, LF Bonewald… - Frontiers in …, 2019 - frontiersin.org
Chemotherapy is frequently accompanied by several side effects, including nausea,
diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that …

Biochemical markers of bone turnover in older adults with type 1 diabetes

MR Rubin, IH De Boer, JYC Backlund… - The Journal of …, 2022 - academic.oup.com
Abstract Context Type 1 diabetes (T1D) is characterized by high fracture risk, yet little is
known regarding diabetes-related mechanisms or risk factors. Objective Determine whether …