Tumour burden and efficacy of immune-checkpoint inhibitors

FG Dall'Olio, A Marabelle, C Caramella… - Nature reviews Clinical …, 2022 - nature.com
Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Tumor burden and immunotherapy: impact on immune infiltration and therapeutic outcomes

SI Kim, CR Cassella, KT Byrne - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but
its efficacy has been variable across patients. Biomarkers to predict such differential …

The oligometastatic spectrum in the era of improved detection and modern systemic therapy

RR Katipally, SP Pitroda, A Juloori… - Nature Reviews …, 2022 - nature.com
Metastases remain the leading cause of cancer-related mortality. The oligometastasis
hypothesis postulates that a spectrum of metastatic spread exists and that some patients …

Predicting pathological highly invasive lung cancer from preoperative [18F]FDG PET/CT with multiple machine learning models

Y Onozato, T Iwata, Y Uematsu, D Shimizu… - European journal of …, 2023 - Springer
Purpose The efficacy of sublobar resection of primary lung cancer have been proven in
recent years. However, sublobar resection for highly invasive lung cancer increases local …

Comprehensive scientometrics and visualization study profiles lymphoma metabolism and identifies its significant research signatures

SB Guo, DQ Pan, N Su, MQ Huang, ZZ Zhou… - Frontiers in …, 2023 - frontiersin.org
Background There is a wealth of poorly utilized unstructured data on lymphoma metabolism,
and scientometrics and visualization study could serve as a robust tool to address this issue …

[HTML][HTML] Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice

AA Pieper, AL Rakhmilevich… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Current clinical trials are using radiation therapy (RT) to enhance an antitumor
response elicited by high-dose interleukin (IL)-2 therapy or immune checkpoint blockade …

Predictive biomarkers for immune-checkpoint inhibitor treatment response in patients with hepatocellular carcinoma

JH Ji, SY Ha, D Lee, K Sankar, EK Koltsova… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) has one of the highest mortality rates among solid cancers.
Late diagnosis and a lack of efficacious treatment options contribute to the dismal prognosis …

Immunotherapy Monitoring with Immune Checkpoint Inhibitors Based on [18F]FDG PET/CT in Metastatic Melanomas and Lung Cancer

E Lopci - Journal of Clinical Medicine, 2021 - mdpi.com
Immunotherapy with checkpoint inhibitors has prompted a major change not only in cancer
treatment but also in medical imaging. In parallel with the implementation of new drugs …

PET/CT molecular imaging in the era of immune-checkpoint inhibitors therapy

Y Gao, C Wu, X Chen, L Ma, X Zhang, J Chen… - Frontiers in …, 2022 - frontiersin.org
Cancer immunotherapy, especially immune-checkpoint inhibitors (ICIs), has paved a new
way for the treatment of many types of malignancies, particularly advanced-stage cancers …

Prognostic value of 18F-FDG PET/CT in patients with advanced or metastatic non-small-cell lung cancer treated with immune checkpoint inhibitors: A systematic …

T Ling, L Zhang, R Peng, C Yue, L Huang - Frontiers in Immunology, 2022 - frontiersin.org
Purpose This study aimed to investigate the value of 18F-fluorodeoxyglucose positron
emission tomography/computed tomography (18F-FDG PET/CT) in predicting early …