Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Thalassaemia is a diverse group of genetic disorders with a worldwide distribution affecting
globin chain synthesis. The pathogenesis of thalassaemia lies in the unbalanced globin …

Inducing fetal hemoglobin (HbF) in red blood cells can alleviate β-thalassemia and sickle
cell disease. We compared five strategies in CD34+ hematopoietic stem and progenitor …

Background Betibeglogene autotemcel (beti-cel) gene therapy for transfusion-dependent β-
thalassemia contains autologous CD34+ hematopoietic stem cells and progenitor cells …

Background Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to
reactivate fetal hemoglobin synthesis through ex vivo clustered regularly interspaced short …

The cardiovascular system requires iron to maintain its high energy demands and metabolic
activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and …

This systematic literature review assessed the global prevalence and birth prevalence of
clinically significant forms of alpha‐and beta‐thalassemia. Embase, MEDLINE, and the …

The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

Background In patients with non-transfusion-dependent β-thalassaemia, haemoglobin
concentrations lower than 10 g/dL are associated with a higher risk of morbidity, mortality …

Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding
clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by …