Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

Cysteinyl leukotrienes (CysLTs) are a family of inflammatory lipid mediators synthesized
from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and …

The 5‐Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene
B4 (LTB4), 5‐oxo‐6E, 8Z, 11Z, 14Z‐eicosatetranoic acid and the cysteinyl leukotrienes …

As described in the introduction to this Perspective series (1), signaling by arachidonic acid
represents a paradigm for the use of oxygen in the transmission of information. At the same …

BACKGROUND Percutaneous transluminal coronary angioplasty (PTCA) is a widely used
and important method of reperfusing coronary arteries. However, it is also associated with …

Background: Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid
metabolism may mediate bronchoconstriction and inflammatory changes important in the …

Lipoxygenase Monooxygenase Phospholipase Oxygen Radicals Leukocyte Pathways
Eosinophils Neutrophils Mast Cells Mononuclear Phagocytes Epithelial Cell Pathways …

Previous studies involving transfection of cDNAs for 5-lipoxygenase-activating protein
(FLAP) and 5-lipoxygenase into osteosarcoma cells have shown that both these proteins are …

BACKGROUND: The ligand activated nuclear hormone receptor peroxisome proliferator-
activated receptor gamma (PPARγ) induces transcriptional repression of pro-inflammatory …

5-Lipoxygenase (5-LO; EC 1.13. 11.34) activity in the human monocytic cell line Mono Mac 6
was upregulated by combined treatment with transforming growth factor beta 1 (TGF-beta) …