Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

The past decade has seen the convergence of a series of new insights that arose from
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …

Females show a disproportionate burden of Alzheimer's disease pathology and higher
Alzheimer's disease dementia prevalences compared to males, yet the mechanisms driving …

Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …

The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …

A diverse heterogeneity of microglial cells was previously described in Alzheimer's disease
(AD) pathology, including dark microglia, a state characterized by ultrastructural markers of …

The transformation of astrocytes into reactive states constitutes a biological response of the
central nervous system under a variety of pathological insults. Astrocytes display diverse …

Abstract Changes in the levels of circulating proteins are associated with Alzheimer's
disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble …

Stroke is one of the leading causes of death worldwide and currently only few therapeutic
options are available. Stroke is a sexually dimorphic disease contributing to the difficulty in …

Microglia, the central nervous system innate immune cells, play a critical role in maintaining
a homeostatic environment in the brain throughout life. These cells exhibit an impressive …