High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Objective Atherosclerotic vascular disease remains the principal cause of death and
disability among patients with type 2 diabetes. Unfortunately, the problem is not adequately …

Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Objective: Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …

Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in
the endoplasmic reticulum stress pathway, linked functionally to activating transcription …