Multi-omics approaches to disease
High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …
genotyping arrays enabled large-scale genome-wide association studies and methods for …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis
Objective Atherosclerotic vascular disease remains the principal cause of death and
disability among patients with type 2 diabetes. Unfortunately, the problem is not adequately …
disability among patients with type 2 diabetes. Unfortunately, the problem is not adequately …
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
GB Ehret, T Ferreira, DI Chasman, AU Jackson… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis
X Sun, JS Seidman, P Zhao, TD Troutman, NJ Spann… - Cell metabolism, 2020 - cell.com
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …
Heme oxygenase-1, oxidation, inflammation, and atherosclerosis
JA Araujo, M Zhang, F Yin - Frontiers in pharmacology, 2012 - frontiersin.org
Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
Heme oxygenases in cardiovascular health and disease
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
Cholesterol-induced phenotypic modulation of smooth muscle cells to macrophage/fibroblast–like cells is driven by an unfolded protein response
Objective: Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …
Human CHAC1 protein degrades glutathione, and mRNA induction is regulated by the transcription factors ATF4 and ATF3 and a bipartite ATF/CRE regulatory …
RR Crawford, ET Prescott, CF Sylvester… - Journal of Biological …, 2015 - ASBMB
Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in
the endoplasmic reticulum stress pathway, linked functionally to activating transcription …
the endoplasmic reticulum stress pathway, linked functionally to activating transcription …