The hypothalamus is a center of convergence and integration of multiple nutrient-related
signals. It can sense changes in circulating adiposity hormones, gastric hormones and …

The neuroendocrine system governs essential survival and homeostatic functions. For
example, growth is needed for development, thermoregulation maintains optimal core …

Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here,
we assessed whether one specific isoform, PKC-θ, was expressed in critical CNS regions …

The central nervous system (CNS) is capable of gathering information on the body's
nutritional state and it implements appropriate behavioral and metabolic responses to …

Evidence obtained in recent years in a few species, especially rainbow trout, supports the
presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central …

Unique subpopulations of specialized metabolic sensing neurons reside in a distributed
network throughout the brain and respond to alterations in ambient levels of various …

We assessed the mechanisms by which specialized hypothalamic ventromedial nucleus
(VMN) neurons utilize both glucose and long-chain fatty acids as signaling molecules to …

The ability for the brain to sense peripheral fuel availability is mainly accomplished within
the hypothalamus, which detects ongoing systemic nutrients and adjusts food intake and …

Fatty acid (FA)-sensitive neurons are present in the brain, especially the hypothalamus, and
play a key role in the neural control of energy and glucose homeostasis including feeding …

Neuronal circuits in the brain help to control feeding behavior and systemic metabolism in
response to afferent nutrient and hormonal signals. Although astrocytes have historically …