Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

Impaired apoptosis plays a central role in cancer development and limits the efficacy of
conventional cytotoxic therapies. Deepening understanding of how opposing factions of the …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

Cells can respond to stress in various ways ranging from the activation of survival pathways
to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a …

Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …

Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …