Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

Abstract The American Society of Regional Anesthesia and Pain Medicine's Third Practice
Advisory on local anesthetic systemic toxicity is an interim update from its 2010 advisory …

Background: The objective of this narrative review of local anesthetic systemic toxicity is to
provide an update on its prevention, diagnosis, and management. Methods: The authors …

Local anesthetics bind reversibly to a specific receptor site within the pore of the Na+
channels in nerves and block ion movement through this pore. When applied locally to …

The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by
local anesthetics, which is reflected in case reports. A systemic review and meta-analysis …

Local anesthetics are widely used clinically for perioperative analgesia to achieve comfort in
medical treatment. However, when the concentration of local anesthetics in the blood …

Biodetoxification using intravenous lipid emulsion (ILE) in acute poisoning is of growing
interest. As well as for local anesthetics, ILE is currently used to reverse toxicity caused by a …

Apelin is an endogenous ligand for the G protein-coupled receptor APJ and has multiple
biological activities in human tissues and organs, including the heart, blood vessels …

The search for novel drugs for the treatment of acute myocardial infarction and reperfusion
injury of the heart is an urgent aim of modern pharmacology. Opioid peptides could be such …