Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly.
It is very rare in children and young adults and the definition is not only based on a low BMD …

Abstract Purpose of Review This review provides suggestions for the evaluation of patients
with osteoporosis in order to assure that the diagnosis is correct, to identify potentially …

Monogenic early onset osteoporosis (EOOP) is a rare disease defined by low bone mineral
density (BMD) that results in increased risk of fracture in children and young adults. Although …

Abstract Purpose of Review The purpose of this review is to summarize recent findings on
copy number variations and susceptibility to osteoporosis. Recent Findings Osteoporosis is …

Abstract Changes in extracellular proton concentrations occur in a variety of tissues over a
range of timescales under physiological conditions and also accompany virtually all …

Background and Objectives: Previous studies have demonstrated that risk of hip fracture is
at least partly heritable. The aim of this study was to determine the magnitude of the genetic …

We present a family with a rare mutation of the LRP6 gene and for the first time provide
evidence for its association with low bone mineral density. Introduction The Wnt pathway …

Idiopathic juvenile osteoporosis (IJO) is a rare condition presenting with vertebral and
metaphyseal fractures that affects otherwise healthy prepubertal children. Bone mineral …

Osteoporosis is caused by the imbalance of osteoblasts and osteoclasts. The regulatory
mechanisms of differentially expressed genes (DEGs) in pathogenesis of osteoporosis are …