Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

RNA has emerged as a revolutionary and important tool in the battle against emerging
infectious diseases, with roles extending beyond its applications in vaccines, in which it is …

A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …

Disclosed herein are compositions and methods of modulating the expression of gene or the
production of a protein by transfecting target cells with nucleic acids. The compositions …

Pulmonary drug and gene delivery to the lung represents a non-invasive avenue for local
and systemic therapies. However, the respiratory tract provides substantial barriers that …

Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …

The advent of nanotechnology has revolutionized drug delivery in terms of improving drug
efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have …

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians
associated with early death. Although the faulty gene is expressed in epithelia throughout …

Ferroptosis has recently become an attractive strategy to combat the chemoresistance of
cancer cells, but the intracellular ferroptosis defense system greatly challenges the efficient …

Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …