Cholesterol is an essential structural component of membranes that contributes to
membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the target of the statins, important
drugs that lower blood cholesterol levels and treat cardiovascular disease. Consequently …

The interest for lupin is continuously growing: one driving force is the numerous studies
showing it provides useful health benefits. This review discusses available literature in the …

Lipid metabolism reprogramming emerges as a new hallmark of malignancies. Sterol
regulatory element-binding proteins (SREBPs), which are central players in lipid …

Prostate cancer (PCa) is the most common cancer in men in developed countries.
Epidemiological studies have associated high blood-cholesterol levels with an increased …

Abstract 3β-Hydroxysterol Δ 24-reductase (DHCR24) catalyzes the conversion of
desmosterol to cholesterol. This ultimate step of cholesterol biosynthesis appears to be …

Previous experiments in suitable animal models and in mild hypercholesterolemic
individuals have shown that the consumption of lupin proteins may be useful for controlling …