During the last 20 years, an expanding body of research has elucidated the central role of
amyloid precursor protein (APP) processing and amyloid β peptide (Aβ) production in the …

The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …

Selective lowering of Aβ42 levels (the 42-residue isoform of the amyloid-β peptide) with
small-molecule γ-secretase modulators (GSMs), such as some non-steroidal anti …

The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

Alzheimer's disease (AD) is the leading cause of dementia and has no cure. Genetic, cell
biological, and biochemical studies suggest that reducing amyloid-β (Aβ) production may …

Genetic variation in SORL1 gene, also known as LR11, has been identified to associate with
Alzheimer's disease (AD) through replicated genetic studies. As a type I transmembrane …

The mevalonate pathway is a crucial metabolic pathway for most eukaryotic cells.
Cholesterol is a highly recognized product of this pathway but growing interest is being …

Excessive proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic
amyloid β peptides (Aβ) by secretases in the brain is a molecular cause of Alzheimer …

Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors
of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal …

Alzheimer's disease (AD), the most common neurodegenerative disorder in the aged, is
characterized by the cerebral deposition of fibrils formed by the amyloid β-protein (Aβ), a 40 …