Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis

M Iddir, A Brito, G Dingeo, SS Fernandez Del Campo… - Nutrients, 2020 - mdpi.com
The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the
World Health Organization. Challenges arise concerning how to optimally support the …

Glutamine: metabolism and immune function, supplementation and clinical translation

V Cruzat, M Macedo Rogero, K Noel Keane, R Curi… - Nutrients, 2018 - mdpi.com
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

G Ma, Z Zhang, P Li, Z Zhang, M Zeng, Z Liang… - Cell Communication and …, 2022 - Springer
Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

The human SLC1A5 (ASCT2) amino acid transporter: from function to structure and role in cell biology

M Scalise, L Pochini, L Console, MA Losso… - Frontiers in cell and …, 2018 - frontiersin.org
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

[图书][B] Amino acids: biochemistry and nutrition

G Wu - 2021 - taylorfrancis.com
Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Glutaminolysis activates Rag-mTORC1 signaling

RV Durán, W Oppliger, AM Robitaille, L Heiserich… - Molecular cell, 2012 - cell.com
Amino acids control cell growth via activation of the highly conserved kinase TORC1.
Glutamine is a particularly important amino acid in cell growth control and metabolism …

The SLC transporter in nutrient and metabolic sensing, regulation, and drug development

Y Zhang, Y Zhang, K Sun, Z Meng… - Journal of molecular cell …, 2019 - academic.oup.com
The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …

[HTML][HTML] A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria …

B Kalyanaraman, G Cheng, M Hardy, O Ouari, M Lopez… - Redox biology, 2018 - Elsevier
The present review is a sequel to the previous review on cancer metabolism published in
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …

Glutamine and intestinal barrier function

B Wang, G Wu, Z Zhou, Z Dai, Y Sun, Y Ji, W Li… - Amino acids, 2015 - Springer
The intestinal barrier integrity is essential for the absorption of nutrients and health in
humans and animals. Dysfunction of the mucosal barrier is associated with increased gut …

[HTML][HTML] Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

M Yuneva, N Zamboni, P Oefner… - The Journal of cell …, 2007 - ncbi.nlm.nih.gov
The idea that conversion of glucose to ATP is an attractive target for cancer therapy has
been supported in part by the observation that glucose deprivation induces apoptosis in …