Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both
endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local …

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Background In westernized societies, acne vulgaris is a nearly universal skin disease
afflicting 79% to 95% of the adolescent population. In men and women older than 25 years …

The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …

The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous
proteins with high binding affinity for IGF-I and IGF-II. Information from NMR and …

TRANSCRIPTIONAL activation of target genes represents an important component of the
tumour-suppressor function of p53 and provides a functional link between p53 and various …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

Traditionally, binding proteins are known to regulate the activity of ligands by prolonging
their half-life, and insulin-like growth factor (IGF)-binding proteins (IGFBPs) are no exception …