Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

A growing body of literature reports on the upregulation of CXC motif chemokine receptor 4
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …

T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-
maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells …

Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …

Rationale: Paradigm shifting studies have revealed that the heart contains functionally
diverse populations of macrophages derived from distinct embryonic and adult …

Sarcoidosis is a multi-system inflammatory disease characterized by the development of
inflammation and noncaseating granulomas that can involve nearly every organ system …

CXC motif chemokine receptor 4 (CXCR4) is expressed on the surface of various cell types
involved in atherosclerosis, with a particularly rich receptor expression on macrophages and …

Inflammatory cell infiltration is central to healing after acute myocardial infarction (AMI). The
relation of regional inflammation to edema, infarct size (IS), microvascular obstruction …

Simple Summary Beyond its pre-eminent role in the context of tumor cell growth as well as
metastasis, the CXC motif chemokine receptor 4 (CXCR4) is a key player in the …

Despite histological evidence in various solid tumor entities, available experience with
CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic …