Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited
Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
[HTML][HTML] Asthma: from bronchoconstriction to airways inflammation and remodeling
J Bousquet, PK Jeffery, WW Busse… - American journal of …, 2000 - atsjournals.org
Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …
[HTML][HTML] Airway remodeling heterogeneity in asthma and its relationship to disease outcomes
A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …
in 2019. The disease is characterized by chronic airway inflammation, reversible …
[HTML][HTML] VEGF and FGF-2: Promising targets for the treatment of respiratory disorders
AP Laddha, YA Kulkarni - Respiratory medicine, 2019 - Elsevier
The endothelial cells play a crucial role in the progression of angiogenesis, which causes
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …
[HTML][HTML] Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
P Flood-Page, A Menzies-Gow… - The Journal of …, 2003 - Am Soc Clin Investig
Eosinophil-derived TGF-β has been implicated in remodeling events in asthma. We
hypothesized that reduction of bronchial mucosal eosinophils with anti–IL-5 would reduce …
hypothesized that reduction of bronchial mucosal eosinophils with anti–IL-5 would reduce …
The role of viruses in acute exacerbations of asthma
DJ Jackson, SL Johnston - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Viral respiratory infections are the most common cause of an acute asthma exacerbation in
both children and adults and represent a significant global health burden. An increasing …
both children and adults and represent a significant global health burden. An increasing …
Inflammatory mediators of asthma: an update
Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …
of many inflammatory and structural cells, all of which release inflammatory mediators that …
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
CG Lee, H Link, P Baluk, RJ Homer, S Chapoval… - Nature medicine, 2004 - nature.com
Exaggerated levels of VEGF (vascular endothelial growth factor) are present in persons with
asthma, but the role (s) of VEGF in normal and asthmatic lungs has not been defined. We …
asthma, but the role (s) of VEGF in normal and asthmatic lungs has not been defined. We …