NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

The impact of stroke on global health is profound, with both high mortality and morbidity
rates. This condition can result from cerebral ischemia, intracerebral hemorrhage (ICH), and …

Stroke is the second leading cause of death globally and the major cause of long-term
disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of …

Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …

Parkinson's disease (PD) is a neurodegenerative disorder that mainly affects the elder
population, and its etiology is enigmatic. Both environmental risks and genetics may …

Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …

Doxorubicin (DOX) is a widely utilized chemotherapeutic agent in clinical oncology for
treating various cancers. However, its clinical use is constrained by its significant side …

Pericyte dysfunction severely undermines cerebrovascular integrity and exacerbates
neurodegeneration in Alzheimer's disease (AD). However, pericyte-targeted therapy is a yet …

Ubiquitination is an intricately regulated post-translational modification that involves the
covalent attachment of ubiquitin to a substrate protein. The complex dynamic nature of the …