The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
The m 6 A RNA methylation is the most prevalent internal modification in mammalian
mRNAs which plays critical biological roles by regulating vital cellular processes …
mRNAs which plays critical biological roles by regulating vital cellular processes …
Function of N6‐methyladenosine modification in tumors
N Zhang, Y Zuo, Y Peng, L Zuo - Journal of oncology, 2021 - Wiley Online Library
N6‐Methyladenosine (m6A) modification is a dynamic and reversible methylation
modification at the N6‐position of adenosine. As one of the most prevalent …
modification at the N6‐position of adenosine. As one of the most prevalent …
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA
N 6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes
degradation of transcripts encoding proteins that have roles in cell development …
degradation of transcripts encoding proteins that have roles in cell development …
Methylation multiplicity and its clinical values in cancer
X Dai, T Ren, Y Zhang, N Nan - Expert reviews in molecular …, 2021 - cambridge.org
Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes
and is associated with diverse differentiation events, physiological activities and human …
and is associated with diverse differentiation events, physiological activities and human …
Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
H Song, D Liu, L Wang, K Liu, C Chen, L Wang, Y Ren… - Molecular cancer, 2022 - Springer
Background Identification of potential novel targets for reversing resistance to Epidermal
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise …
Programmable protein expression using a genetically encoded m6A sensor
BF Marayati, MG Thompson, CL Holley… - Nature …, 2024 - nature.com
Abstract The N 6-methyladenosine (m6A) modification is found in thousands of cellular
mRNAs and is a critical regulator of gene expression and cellular physiology. m6A …
mRNAs and is a critical regulator of gene expression and cellular physiology. m6A …
The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis
Y Li, L Meng, B Zhao - Pharmacology & therapeutics, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A), a novel epitranscriptomic RNA modification, plays
crucial roles in a variety of biological processes and diseases. Recently, there are growing …
crucial roles in a variety of biological processes and diseases. Recently, there are growing …
m6A-express: uncovering complex and condition-specific m6A regulation of gene expression
T Zhang, SW Zhang, SY Zhang, SJ Gao… - Nucleic acids …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) is the most abundant form of mRNA modification and
controls many aspects of RNA metabolism including gene expression. However, the …
controls many aspects of RNA metabolism including gene expression. However, the …
M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis
W Guo, C Zhang, P Feng, M Li, X Wang, Y Xia, D Chen… - Oncogene, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulator in
cancer. However, the understanding of m6A modification on lipid metabolism regulation in …
cancer. However, the understanding of m6A modification on lipid metabolism regulation in …
MEX3C-mediated decay of SOCS3 mRNA promotes JAK2/STAT3 signaling to facilitate metastasis in hepatocellular carcinoma
Y Xiao, Y Li, D Shi, X Wang, S Dai, M Yang, L Kong… - Cancer Research, 2022 - AACR
Tumor metastasis is one of the major causes of high mortality in patients with hepatocellular
carcinoma (HCC). Sustained activation of STAT3 signaling plays a critical role in HCC …
carcinoma (HCC). Sustained activation of STAT3 signaling plays a critical role in HCC …