Treatments Targeting the Androgen Receptor and Its Splice Variants in Breast Cancer
AH Tien, MD Sadar - International Journal of Molecular Sciences, 2024 - mdpi.com
Breast cancer is a major cause of death worldwide. The complexity of endocrine regulation
in breast cancer may allow the cancer cells to escape from a particular treatment and result …
in breast cancer may allow the cancer cells to escape from a particular treatment and result …
In touch with your feminine side: how oestrogen metabolism impacts prostate cancer
Prostate cancer is the primary cancer in males, with increasing global incidence rates
making this malignancy a significant healthcare burden. Androgens not only promote normal …
making this malignancy a significant healthcare burden. Androgens not only promote normal …
Discovery of highly potent proapoptotic antiestrogens in a series of androst-5, 16-dienes D-modified with imidazole-annulated pendants
V Birukova, A Scherbakov, A Ilina, D Salnikova… - The Journal of Steroid …, 2023 - Elsevier
Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
Gene expression signature predictive of neuroendocrine transformation in prostate adenocarcinoma
Neuroendocrine prostate cancer (NEPC) can arise de novo, but much more commonly
occurs as a consequence of a selective pressure from androgen deprivation therapy or …
occurs as a consequence of a selective pressure from androgen deprivation therapy or …
A nine-gene signature identification and prognostic risk prediction for patients with lung adenocarcinoma using novel machine learning approach
Background Lung adenocarcinoma (LUAD) is one the most prevalent cancer with high
mortality and its risk stratification is limited due lack of reliable molecular biomarkers …
mortality and its risk stratification is limited due lack of reliable molecular biomarkers …
A knowledge graph completion method applied to literature-based discovery for predicting missing links targeting cancer drug repurposing
Cancer literature contains a rich body of implicit knowledge which can play an important role
in drug repurposing. However, classical knowledge retrieval techniques used in Literature …
in drug repurposing. However, classical knowledge retrieval techniques used in Literature …
Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant
Context Autosomal dominant and rarely de novo gain-of-function variants in the LHCGR
gene are associated with precocious male puberty, while somatic LHCGR variants have …
gene are associated with precocious male puberty, while somatic LHCGR variants have …
Design and synthesis of phosphoryl-substituted steroidal pyridazines (Pho-STPYRs) as potent estrogen receptor alpha inhibitors: targeted treatment of hormone …
Estrogen receptor alpha (ERα) is an important target for the discovery of new therapeutic
drugs against hormone-dependent breast cancer. A series of phosphoryl-substituted …
drugs against hormone-dependent breast cancer. A series of phosphoryl-substituted …
Family matters: collaboration and conflict among the steroid receptors raises a need for group therapy
MJ Sikora - Endocrinology, 2016 - academic.oup.com
Antiestrogen therapies targeting the function of estrogen receptor (ER) have been the
cornerstone of therapy for ER+ breast cancer for decades. However, as long as these …
cornerstone of therapy for ER+ breast cancer for decades. However, as long as these …
Amino polycarboxylic acids-modified abiraterone derivatives as potential injectable anti-prostate cancer agents
N Zhu, S Meng, L Mao, Y Rong, X Wang, Y Liu… - Bioorganic …, 2024 - Elsevier
Abiraterone (Abi), an effective cytochrome oxidase P450 C17 (CYP17) inhibitor, inhibits
androgen synthesis in testes, adrenal glands, and prostate tumors. However, their low …
androgen synthesis in testes, adrenal glands, and prostate tumors. However, their low …