Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive
decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in …

Introduction Neuropathic pain (NP) significantly impacts quality of life and often coexists with
affective disorders such as anxiety and depression. Addressing both NP and its psychiatric …

Background: Mixtures of gabapentin, tramadol and/or amitriptyline are usually
recommended for treatment of neuropathic pain. Materials & methods/results: A novel GC …

Tramadol (TRM) and pregabalin (PGB) are frequently used in combination for neuropathic
pain management. Accordingly, a selective and sensitive high-performance liquid …

Neuropathic pain (NP) is a common public health problem that poses a major challenge to
basic scientists and health-care providers. NP is a complex problem with an unclear etiology …

Ethnopharmacological relevance Luehea divaricata, popularly known in Brazil as “açoita-
cavalo”, has been widely explored by different ethnic groups native to Brazil to treat different …

Background Mouse models of inflammatory bowel disease (IBD) identify an impact on the
enteric nervous system (ENS) but do not distinguish between Crohn's disease and …

Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor
(MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in …

Neuropathic pain is characterized by the presence of hyperalgesia and allodynia.
Pharmacological treatments include the use of antiepileptics such as pregabalin or …

The introduced research presents a novel in vivo quantitative method for assay of mixtures
of pregabalin and tramadol as a common combinations approved for treatment of …