[HTML][HTML] Combination therapy for neuropathic pain: a review of recent evidence
A Serrano Afonso, T Carnaval… - Journal of Clinical …, 2021 - mdpi.com
Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive
decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in …
decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in …
Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence
DRA Coelho, M Gersten, AS Jimenez, F Fregni… - Pain …, 2024 - Wiley Online Library
Introduction Neuropathic pain (NP) significantly impacts quality of life and often coexists with
affective disorders such as anxiety and depression. Addressing both NP and its psychiatric …
affective disorders such as anxiety and depression. Addressing both NP and its psychiatric …
US FDA-validated green GC–MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids
Background: Mixtures of gabapentin, tramadol and/or amitriptyline are usually
recommended for treatment of neuropathic pain. Materials & methods/results: A novel GC …
recommended for treatment of neuropathic pain. Materials & methods/results: A novel GC …
[HTML][HTML] ESI–LC–MS/MS for therapeutic drug monitoring of binary mixture of pregabalin and tramadol: Human plasma and urine applications
Tramadol (TRM) and pregabalin (PGB) are frequently used in combination for neuropathic
pain management. Accordingly, a selective and sensitive high-performance liquid …
pain management. Accordingly, a selective and sensitive high-performance liquid …
[HTML][HTML] Efficacy of a combination of N-palmitoylethanolamide, beta-caryophyllene, carnosic Acid, and myrrh extract on chronic neuropathic pain: a preclinical study
Y Fotio, A Aboufares El Alaoui, AM Borruto… - Frontiers in …, 2019 - frontiersin.org
Neuropathic pain (NP) is a common public health problem that poses a major challenge to
basic scientists and health-care providers. NP is a complex problem with an unclear etiology …
basic scientists and health-care providers. NP is a complex problem with an unclear etiology …
Aqueous extract from Luehea divaricata Mart. leaves reduces nociception in rats with neuropathic pain
A Kroth, MCQ Santos, TCB da Silva… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Luehea divaricata, popularly known in Brazil as “açoita-
cavalo”, has been widely explored by different ethnic groups native to Brazil to treat different …
cavalo”, has been widely explored by different ethnic groups native to Brazil to treat different …
Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine
MG Blennerhassett, SR Lourenssen… - …, 2017 - Wiley Online Library
Background Mouse models of inflammatory bowel disease (IBD) identify an impact on the
enteric nervous system (ENS) but do not distinguish between Crohn's disease and …
enteric nervous system (ENS) but do not distinguish between Crohn's disease and …
Involvement of the peripheral μ-opioid receptor in tramadol-induced constipation in rodents
K Yasufuku, K Koike, M Kobayashi, H Chiba… - Biological and …, 2021 - jstage.jst.go.jp
Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor
(MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in …
(MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in …
Sigma‐1 receptor antagonist (BD‐1063) potentiates the antinociceptive effect of quercetin in neuropathic pain induced by chronic constriction injury
JV Espinosa‐Juárez… - Drug Development …, 2021 - Wiley Online Library
Neuropathic pain is characterized by the presence of hyperalgesia and allodynia.
Pharmacological treatments include the use of antiepileptics such as pregabalin or …
Pharmacological treatments include the use of antiepileptics such as pregabalin or …
Ecologically evaluated and FDA‐validated HPTLC method for assay of pregabalin and tramadol in human biological fluids
The introduced research presents a novel in vivo quantitative method for assay of mixtures
of pregabalin and tramadol as a common combinations approved for treatment of …
of pregabalin and tramadol as a common combinations approved for treatment of …