Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-
Saharan Africa. We present the sequence and analysis of the 11 megabase-sized …

Some development stages of the trypanosomatid protozoan parasites are well adapted to in
vitro culture. They can be maintained in rich medium containing large excess of glucose and …

Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Biochemistry textbooks depict mitochondria as oxygen-dependent organelles, but many
mitochondria can produce ATP without using any oxygen. In fact, several other types of …

The long slender bloodstream form Trypanosoma brucei maintains its essential
mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1 …

The evolutionary processes underlying the differentness of prokaryotic and eukaryotic cells
and the origin of the latters organelles are still poorly understood. For about 100 years, the …

Proline metabolism has been studied in procyclic form Trypanosoma brucei. These
parasites consume six times more proline from the medium when glucose is in limiting …

Kinetoplastida are protozoan organisms that probably diverged early in evolution from other
eukaryotes. They are characterized by a number of unique features with respect to their …