Airway surface liquid pH regulation in airway epithelium current understandings and gaps in knowledge

M Zajac, E Dreano, A Edwards, G Planelles… - International journal of …, 2021 - mdpi.com
Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives

MA Selo, JA Sake, KJ Kim, C Ehrhardt - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

High-speed multifunctional scanning ion conductance microscopy: Innovative strategies to study dynamic cellular processes

E Tognoni - Current Opinion in Electrochemistry, 2021 - Elsevier
The latest contributions of scanning ion conductance microscopy (SICM) to current research
in life sciences are reviewed. The continued efforts toward technical improvements in SICM …

Research on the adaptive sensitivity scanning method for ion conductance microscopy with high efficiency and reliability

Y Jiao, J Zhuang, T Zhang, L He - Analytical chemistry, 2021 - ACS Publications
Scanning ion conductance microscopy (SICM) is a type of in situ measurement technology
for noncontact detection of samples in electrolytes with nanoscale resolution and has been …

Applications of scanning ion conductance microscope in biomedical fields

X Gong, X Fan, Y Huang, Y Du, X Wang… - MedComm …, 2023 - Wiley Online Library
Scanning ion conductance microscopy (SICM) is a scanning probe technique to reflect the
surface morphology of the sample with the probe's motion trajectory through measuring the …

A high accuracy ion conductance imaging method based on the approach curve spectrum

Y Jiao, J Zhuang, Q Zheng, X Liao - Ultramicroscopy, 2020 - Elsevier
Scanning ion conductance microscopy (SICM), as an emerging non-contact in situ
topography measurement tool with nano resolution, has been increasingly used in recent …

Preliminary Exploration of a DNA Editing Strategy to Treat Cystic Fibrosis using Homology-Independent Targeted Integration and Receptor-Targeted Nanoparticles

C Graham - 2024 - discovery.ucl.ac.uk
Cystic fibrosis (CF) is a common life-limiting disorder. Dysfunctional cystic fibrosis
transmembrane conductance regulator (CFTR) protein hinders mucociliary clearance in the …

Developing and testing a theoretical framework for airway surface liquid homeostasis

O Hamed, GWJ Moss, V Dua - 2024 - discovery.ucl.ac.uk
The airway surface liquid (ASL) is a thin fluid layer (0.1-10 µm) lining the airway epithelium
which plays several important roles in normal lung function. These include preventing …

BK channel modulation as a theraputic target for Cystic Fibrosis

A Mitchell, D Benton, G Moss, V Dua - 2023 - discovery.ucl.ac.uk
Background. Cystic fibrosis and is caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR), an anion channel present on the apical membrane of airway …