Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

Methanol has been historically considered an exogenous product that leads only to
pathological changes in the human body when consumed. However, in normal, healthy …

Chronic alcohol abuse causes liver disease that progresses from simple steatosis through
stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes
ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased …

Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes
that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases …

Migraine is a disease for which there is still no defined pathophysiological etiology and few
translational models. The organic nitrate nitroglycerin has been in use as an experimental …