Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem
disorder with considerable extra-motor involvement. The neuropsychological manifestations …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Background Gait impairment is poorly characterized in amyotrophic lateral sclerosis (ALS),
despite increasing evidence of extrapyramidal and cerebellar dysfunction. Gait impairment …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …