The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

The “Hippo” signaling pathway has emerged as a major regulator of cell proliferation and
survival in metazoans. The pathway, as delineated by genetic and biochemical studies in …

Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …

The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

The Mst–Lats kinase cascade is central to the Hippo tumor-suppressive pathway that
controls organ size and tissue homeostasis. The adaptor protein Mob1 promotes Lats …

We present a high content multiwell plate cell-based assay approach to quantify protein
interactions directly in cells using Förster resonance energy transfer (FRET) read out by …

During interphase, centrosomes are held together by a proteinaceous linker that connects
the proximal ends of the mother and daughter centriole. This linker is disassembled at the …