Chromosome replication in Escherichia coli is normally initiated at oriC, the origin of
chromosome replication. E. coli cells possess at least three additional initiation systems for …

Malaria remains a significant threat to global health, and despite concerted efforts to curb the
disease, malaria-related morbidity and mortality increased in recent years. Malaria is caused …

Abstract Analysis of mammalian mtDNA by two-dimensional agarose gel electrophoresis
revealed two classes of replication intermediate. One was resistant to single-strand …

The switching of parasitic organisms to novel hosts, in which they may cause the emergence
of new diseases, is of great concern to human health and the management of wild and …

Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action
remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we …

Atovaquone represents a class of antimicrobial agents with a broad‐spectrum activity
against various parasitic infections, including malaria, toxoplasmosis and Pneumocystis …

Using two‐dimensional agarose gel electrophoresis, we show that mitochondrial DNA
(mtDNA) replication of birds and mammals frequently entails r ibonucleotide i ncorporation t …

While the majority of DNA is enclosed within the nucleus, the mitochondria also contain their
own, separate DNA, the mitochondrial DNA (mtDNA). Mutations in mtDNA are associated …

Previous data from our laboratory suggested that replication of mammalian mitochondrial
DNA initiates exclusively at or near to the formerly designated origin of heavy strand …

Mounting evidence suggests that key components of the mitochondrial transcription and
replication apparatus are derived from the T-odd lineage of bacteriophage rather than from …