Immune imprinting and next-generation coronavirus vaccines
CQ Huang, S Vishwanath, GW Carnell, ACY Chan… - Nature …, 2023 - nature.com
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning
As the COVID-19 pandemic has evolved during the past years, interactions between human
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
A Yisimayi, W Song, J Wang, F Jian, Y Yu, X Chen… - Nature, 2024 - nature.com
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …
vaccine compositions. However, immune imprinting induced by vaccination based on the …
Molecular fate-mapping of serum antibody responses to repeat immunization
A Schiepers, MFL van't Wout, AJ Greaney, T Zang… - Nature, 2023 - nature.com
The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
Original SARS-CoV-2 monovalent and Omicron BA. 4/BA. 5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results
S Chalkias, JL Whatley, F Eder, B Essink, S Khetan… - Nature Medicine, 2023 - nature.com
This ongoing, open-label, phase 2/3 trial compared the safety and immunogenicity of the
Omicron BA. 4/BA. 5-containing bivalent mRNA-1273.222 vaccine with the ancestral Wuhan …
Omicron BA. 4/BA. 5-containing bivalent mRNA-1273.222 vaccine with the ancestral Wuhan …
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB. 1.5 mRNA booster in humans
Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
Evolution of antibody immunity following Omicron BA. 1 breakthrough infection
Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-
CoV-2 breakthrough infection will inform the development of next-generation vaccines …
CoV-2 breakthrough infection will inform the development of next-generation vaccines …
[HTML][HTML] Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine
To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines,
encoding both ancestral and Omicron BA. 5 spikes, have replaced monovalent vaccines in …
encoding both ancestral and Omicron BA. 5 spikes, have replaced monovalent vaccines in …
A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses
The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …
was designed to prime VRC01-class HIV-specific B cells that would need to be matured …