Zika virus

LR Petersen, DJ Jamieson, AM Powers… - New England Journal …, 2016 - Mass Medical Soc
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Zika virus: history of a newly emerging arbovirus

N Wikan, DR Smith - The Lancet Infectious Diseases, 2016 - thelancet.com
Zika virus was originally identified in a sentinel rhesus monkey in the Zika Forest of Uganda
in 1947. The virus is a member of the family Flaviviridae, genus Flavivirus, and is transmitted …

A mouse model of Zika virus pathogenesis

HM Lazear, J Govero, AM Smith, DJ Platt… - Cell host & …, 2016 - cell.com
The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including
Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models …

Zika virus infection with prolonged maternal viremia and fetal brain abnormalities

RW Driggers, CY Ho, EM Korhonen… - … England Journal of …, 2016 - Mass Medical Soc
The current outbreak of Zika virus (ZIKV) infection has been associated with an apparent
increased risk of congenital microcephaly. We describe a case of a pregnant woman and …

Persistence of Zika virus in body fluids

G Paz-Bailey, ES Rosenberg, K Doyle… - … England Journal of …, 2018 - Mass Medical Soc
Background To estimate the frequency and duration of detectable Zika virus (ZIKV) RNA in
human body fluids, we prospectively assessed a cohort of recently infected participants in …

Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy

Q Liang, Z Luo, J Zeng, W Chen, SS Foo, SA Lee, J Ge… - Cell stem cell, 2016 - cell.com
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …

[HTML][HTML] Zika virus: History, epidemiology, transmission, and clinical presentation

BH Song, SI Yun, M Woolley, YM Lee - Journal of neuroimmunology, 2017 - Elsevier
Zika virus (ZIKV), a mosquito-borne positive-stranded RNA virus of the family Flaviviridae
(genus Flavivirus), is now causing an unprecedented large-scale outbreak in the Americas …

Assessing the global threat from Zika virus

J Lessler, LH Chaisson, LM Kucirka, Q Bi, K Grantz… - Science, 2016 - science.org
BACKGROUND First discovered in 1947, Zika virus (ZIKV) received little attention until a
surge in microcephaly cases was reported after a 2015 outbreak in Brazil. The size of the …

Prevention and control of Zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis

D Gao, Y Lou, D He, TC Porco, Y Kuang, G Chowell… - Scientific reports, 2016 - nature.com
The ongoing Zika virus (ZIKV) epidemic in the Americas poses a major global public health
emergency. While ZIKV is transmitted from human to human by bites of Aedes mosquitoes …

Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection

LJ Yockey, L Varela, T Rakib, W Khoury-Hanold… - Cell, 2016 - cell.com
Zika virus (ZIKV) can be transmitted sexually between humans. However, it is unknown
whether ZIKV replicates in the vagina and impacts the unborn fetus. Here, we establish a …