The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new
area of research that has led to the discovery of several life-saving antimicrobial agents …

The delivery of a drug to a specific organ or tissue at an efficacious concentration is the
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …

Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the
genus Babesia. With its increasing incidence worldwide and the risk of human-to-human …

The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of
many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi …

Malaria is a tropical threatening disease caused by Plasmodium parasites, resulting in
409,000 deaths in 2019. The delay of mortality and morbidity has been compounded by the …

Though morbidity and mortality due to malaria have declined in the last 15 years, emerging
resistance to first-line artemisinin-based antimalarials, absence of efficacious vaccines and …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

The rise of antibiotic resistance necessitates the search for new platforms for drug
development. Prodrugs are common tools for overcoming drawbacks typically associated …

Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases that
mediate membrane dynamics or organellar fission/fusion events. Plasmodium falciparum …

Toxoplasma gondii is a common zoonotic infection of humans, and estimates indicate that 1–
2 billion people are chronically infected. Although largely asymptomatic, chronic infection …