Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …
polyphenol compounds that have been shown to offer numerous health benefits …
Indolepropionic acid, a gut bacteria-produced tryptophan metabolite and the risk of type 2 diabetes and non-alcoholic fatty liver disease
R Sehgal, VD de Mello, V Männistö, J Lindström… - Nutrients, 2022 - mdpi.com
An intricate relationship between gut microbiota, diet, and the human body has recently
been extensively investigated. Gut microbiota and gut-derived metabolites, especially …
been extensively investigated. Gut microbiota and gut-derived metabolites, especially …
Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms
We investigated the impact of Coartem™(COA) and aflatoxin B1 (AFB1) on rats'
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases
Z Luo, Y Liu, X Wang, F Fan, Z Yang, D Luo - Biochemical Pharmacology, 2024 - Elsevier
The rapidly rising prevalence of metabolic diseases has turned them into an escalating
global health concern. By producing or altering metabolic products, the gut microbiota plays …
global health concern. By producing or altering metabolic products, the gut microbiota plays …
Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis
We examined the protective effect of the apigeninidin (API)-enriched fraction from Sorghum
bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B1 (AFB1)-induced …
bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B1 (AFB1)-induced …
Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015–2018 National Health and Nutrition …
Y Wu, X Weng, S Liu, Y Tan, H Liang, Y Li… - … Science and Pollution …, 2023 - Springer
Substantial evidence has shown that organophosphate pesticide (OPP) exposure altered
the reproductive system functions, such as prolonged menstrual cycles, sexual hormone …
the reproductive system functions, such as prolonged menstrual cycles, sexual hormone …
The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats
Abstract Aflatoxin B1 (AFB1) is known to derange the hepatorenal system by redox, DNA
adduct formation and apoptotic networks. Endogenous 3‐indole propionic acid (3‐IPA) is a …
adduct formation and apoptotic networks. Endogenous 3‐indole propionic acid (3‐IPA) is a …
Determination of tryptophan and its indole metabolites in follicular fluid of women with diminished ovarian reserve
A Liu, H Shen, Q Li, J He, B Wang, W Du, G Li… - Scientific Reports, 2023 - nature.com
Tryptophan (TRP) and its indole metabolites exhibit numerous biological effects, especially
their antioxidant properties. This study used untargeted metabolomics in conjunction with …
their antioxidant properties. This study used untargeted metabolomics in conjunction with …
3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and …
The application of chlorpyrifos (CPF), an organophosphorus pesticide to control insects, is
associated with oxidative stress and reduced quality of life in humans and animals. Indole-3 …
associated with oxidative stress and reduced quality of life in humans and animals. Indole-3 …
Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation
SE Owumi, GE Adebisi, OA Odunola - Chemico-Biological Interactions, 2023 - Elsevier
Abstract The “anthracycline, Epirubicin (EPI),” in managing breast cancer, is highly cytotoxic.
Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its …
Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its …