Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

The role of decidual immune cells on human pregnancy

S Liu, L Diao, C Huang, Y Li, Y Zeng… - Journal of reproductive …, 2017 - Elsevier
The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …

VEGF may contribute to macrophage recruitment and M2 polarization in the decidua

KC Wheeler, MK Jena, BS Pradhan, N Nayak, S Das… - PloS one, 2018 - journals.plos.org
It is increasingly evident that cytokines and growth factors produced in the decidua play a
pivotal role in the regulation of the local immune microenvironment and the establishment of …

M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1/M2 monocytes to osteoclastogenesis

S Fukui, N Iwamoto, A Takatani, T Igawa… - Frontiers in …, 2018 - frontiersin.org
Objectives We investigated the relationships among M1 monocytes, M2 monocytes,
osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid …

Human chorionic villous differentiation and placental development

J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

Endogenous and uric acid-induced activation of NLRP3 inflammasome in pregnant women with preeclampsia

ML Matias, M Romao, IC Weel, VR Ribeiro, PR Nunes… - PloS one, 2015 - journals.plos.org
Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and
proteinuria. This pathology is associated with hyperuricemia and elevated serum levels of …

COVID-19, pre-eclampsia, and complement system

C Agostinis, A Mangogna, A Balduit… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together
with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with …

Innate and adaptive immune systems in physiological and pathological pregnancy

J Weng, C Couture, S Girard - Biology, 2023 - mdpi.com
Simple Summary Pregnancy is a continually evolving process with many moving parts that
must be tightly regulated on both the maternal and fetal sides to ensure its success. A …

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia

ML Matias, VJ Gomes, M Romao-Veiga, VR Ribeiro… - Molecules, 2019 - mdpi.com
Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of
cells from the innate immune system. The present study evaluated whether silibinin (SB) …

Trophoblast-derived extracellular vesicles promote preeclampsia by regulating macrophage polarization

X Liu, H Fei, C Yang, J Wang, X Zhu, A Yang, Z Shi… - …, 2022 - Am Heart Assoc
BACKGROUND: Systemic inflammation caused by dysfunctional macrophages is a crucial
pathogenetic event in preeclampsia (PE). Trophoblast-derived extracellular vesicles (T-EVs) …