Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3, 4-
dihydropyrimidin-2 (1H)-ones/thiones (DHPMs) have emerged as prototypes for the design …

The review analyzes methods of synthesis of 1, 4-oxazines (morpholines) starting from
vicinal amino alcohols and their derivatives, oxiranes, and aziridines. Examples of using …

Background: This review elaborates the updated synthetic and pharmacological approaches
of a known group of dihydropyrimidinones/thiones from the multi-component reaction like …

The review is summarized and systematized the published data on the multicomponent
reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and …

We described the first synthesis of fatty acid 3, 4-dihydropyrimidinones (DHPM-fatty acids)
using the Biginelli multicomponent reaction. Antiproliferative activity on two glioma cell lines …

Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal
cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and …

Purpose: To evaluate the antihepatotoxic activity of dihydropyrimidinone derivative linked
with 1, 4-benzodioxane. Methods: A series of novel dihydropyrimidinone derivatives linked …

Cancer is a serious disease that has been around for a long time but currently has no
sustainable solution. Several medications currently available offer an opportunity for the …

Years after the first report on 1, 4-dihydropyridines (1, 4-DHPs) and 1, 2, 3, 4-
tetrahydropyrimidines (1, 2, 3, 4-THPMs) appeared, they are revisited as plausible …