T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
IL-17 and IL-17-producing cells in protection versus pathology
KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …
immunity against many pathogens but also driving inflammatory pathology during infection …
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation
S Federici, S Kredo-Russo, R Valdés-Mas… - Cell, 2022 - cell.com
Human gut commensals are increasingly suggested to impact non-communicable diseases,
such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a …
such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a …
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …
responses, but the mechanisms controlling these distinct outcomes remain poorly …
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
MLJ Watson, PDA Vignali, SJ Mullett… - Nature, 2021 - nature.com
Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease
Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …
addition to genetics and host biology, environment has a large and irreversible role in the …
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis
The metabolic pathways encoded by the human gut microbiome constantly interact with host
gene products through numerous bioactive molecules. Primary bile acids (BAs) are …
gene products through numerous bioactive molecules. Primary bile acids (BAs) are …
Control of immunity by the microbiota
The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
sites that are collectively known as the microbiota. It is increasingly clear that microbial …
The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries
Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …
Treg heterogeneity, function, and homeostasis
D Shevyrev, V Tereshchenko - Frontiers in immunology, 2020 - frontiersin.org
T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …