Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous
macromolecular networks on a proteome scale, but current methods are experimentally …

Antibodies play an important role in the immune system by binding to molecules called
antigens at their respective epitopes. These interfaces or epitopes are structural entities …

It has been demonstrated earlier that the neural network based program AlphaFold2 can be
used to dock proteins given the two sequences separated by a gap as the input. The …

Background This world is currently witnessing a pandemic outbreak of 'COVID-19′ caused
by a positive-strand RNA virus 'SARS-CoV-2'. Millions have succumbed globally to the …

Proteins play crucial roles in every cellular process by interacting with each other, nucleic
acids, metabolites, and other molecules. The resulting assemblies can be very large and …

The process of creating a model of the structure formed by a pair of interacting molecules is
commonly referred to as docking. Protein docking is one of the most studied topics in …

Drug discovery often begins with a new target. Protein–protein interactions (PPIs) are crucial
to multitudinous cellular processes and offer a promising avenue for drug-target discovery …

Background: Proteins are biological macromolecules that interact with each other,
performing various functions and regulate many biological processes, making them vital to …

3.2. 1 Coarse-Grained Representation ssRNA'TTRACT uses a coarse-grained
representation and a knowledge-based scoring function [168, 257, 256]. Each amino acid is …

Detection and analysis of protein-ligand binding sites is an important area of research in
drug discovery. The FTMap web server is an established computational method for detection …