Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive
inflammation, and support tissue repair processes. Therefore, Treg cells are currently …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

A primary goal in transplantation medicine is the induction of a tolerogenic environment for
prevention of transplant rejection without the need for long-term pharmacological …

Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and
impede post-stroke brain recovery. CD4+ CD25+ Foxp3+ regulatory T (Treg) cells play …

Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote
transplant tolerance. The relationship between CAR structure and Treg function was studied …

Highlights•'Next generation'Treg cell therapy products will use genetic engineering to
enhance function.•Methods to scale up Treg cell therapy products depend on cell source …

Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in
treating certain tumors has led to numerous studies exploring its potential application to treat …

Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …

Hematopoietic chimerism remains the most promising strategy to bring transplantation
tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the …

Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option
for both autoimmune and alloimmune diseases. However, numerous challenges remain …