The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …

Colibactin is a secondary metabolite encoded by the pks gene island identified in several
Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC)
screening, prevention and treatment. Here, first, we demonstrate selective colonization of …

Colorectal cancer (CRC), the third most common cancer in the world, has been recently
rising in emerging countries due to environmental and lifestyle factors. Many of these factors …

Simple Summary Gut microbiota is emerging as new diagnostic and prognostic marker
and/or therapeutic target to improve the management of cancer. This review aims to …

Co-culture of intestinal organoids with a colibactin-producing pks+ E. coli strain (EcC)
revealed mutational signatures also found in colorectal cancer (CRC). E. coli Nissle 1917 …

Diverse microbial communities colonize different habitats of the human body, including gut,
oral cavity, nasal cavity and tissues. These microbial communities are known as human …

Dietary patterns and specific dietary components, in concert with the gut microbiota, can
jointly shape susceptibility, resistance and therapeutic response to cancer. Which diet …

Colibactin produced primarily by Escherichia coli strains of the B2 phylogroup cross-links
DNA and can promote colon cancer in human hosts. Here, we investigate the toxin's impact …