The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation,
apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Purpose: Pancreatic cancer is characterized by stromal desmoplasia and perineural
invasion (PNI). We sought to explore the contribution of pancreatic stellate cells (PSC) …

Nerve regeneration includes regrowth of injured axons as well as myelination, restoration of
synaptic connections and recovery of physiological functions. Platelet-rich plasma (PRP) is …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
very poor prognosis. To date patient outcomes have not improved principally due to the …

Perineural invasion (PNI) is defined as the presence of neoplastic cells along nerves and/or
within the different layers of nervous fibers: epineural, perineural and endoneural spaces. In …

Simple Summary Cancer-associated fibroblasts, which are derived from several cell types
such as pancreatic stellate cells or mesenchymal stem cells, play a major role in the …

Interaction of cancer cells with diverse cell types in the tumor stroma is today recognized to
have a fate-determining role for the progression and outcome of human cancers. Despite the …

Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence
ratio. Traditional therapeutic approaches such as surgery in combination with chemo-or …

Objective Pain is the main problem for patients with osteoarthritis (OA). Pain is linked to
inflammation, but in OA a subset of patients suffers from pain without inflammation …