Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …

Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-
induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of …

Of the hepatic cell lines developed for in vitro studies of hepatic functions as alternatives to
primary human hepatocytes, many have lost major liver-like functions, but not HepaRG cells …

Forsythia fruit, edible fruit of Forsythia suspensa (Thunb.) Vahl, which has been found to be
effective in treating cholestasis. However, its key component for alleviating cholestasis has …

Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver
reactions. Although expression of human leukocyte antigen (HLA)-B* 57: 01 increases …

Endoplasmic reticulum (ER) stress has been associated with various drug–induced liver
lesions but its participation in drug-induced cholestasis remains unclear. We first aimed at …

Trastuzumab (TZMB) is widely used as first line therapy for breast cancer (BC) patients
overexpressing human epidermal growth factor receptor 2 (HER2). Despite its clinical …

Cholestasis is derived from the Greek words chole meaning bile and stasis indicating halting
(Noor 2015), and denotes any situation of impaired bile secretion with concomitant …

Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver
injury. Although expression of HLA-B* 57: 01 is associated with increased susceptibility, little …

Cholestasis can be defined as any situation of impaired bile secretion with concomitant
accumulation of bile acids in the liver or in the systemic circulation. A variety of factors may …