Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment.
Mitochondria are major consumers of oxygen and a potential source of reactive oxygen …

Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Cysteine residues are concentrated at key functional sites within proteins, performing
diverse roles in metal binding, catalysis, and redox chemistry. Chemoproteomic platforms to …

This review presents current knowledge related to VDAC1 as a multi-functional
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Unraveling the role of VDAC3 within living cells is challenging and still requires a definitive
answer. Unlike VDAC1 and VDAC2, the outer mitochondrial membrane porin 3 exhibits …

Apoptosis is thought to play a critical role in several pathological processes, such as
neurodegenerative diseases (ie Parkinson's and Alzheimer's diseases) and various …

Abstract Voltage Dependent Anion-selective Channel 2 (VDAC2) contributes to oxidative
metabolism by sharing a role in solute transport across the outer mitochondrial membrane …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Tumor growth and progression is characteristically associated with the synergistic effects of
uncontrolled cellular proliferation and cell survival under stress. Pyruvate kinase M2 (PKM2) …