Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Importance Heritability describes the proportion of variance in the risk of developing a
condition that is explained by genetic factors. Although amyotrophic lateral sclerosis (ALS) is …