Recent developments on therapeutic and diagnostic approaches for COVID-19
J Majumder, T Minko - The AAPS journal, 2021 - Springer
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health …
Remdesivir against COVID-19 and other viral diseases
JJ Malin, I Suárez, V Priesner… - Clinical microbiology …, 2020 - Am Soc Microbiol
Patients and physicians worldwide are facing tremendous health care hazards that are
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …
Cryptic and abundant marine viruses at the evolutionary origins of Earth's RNA virome
Whereas DNA viruses are known to be abundant, diverse, and commonly key ecosystem
players, RNA viruses are insufficiently studied outside disease settings. In this study, we …
players, RNA viruses are insufficiently studied outside disease settings. In this study, we …
Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny
RC Edgar - Nature Communications, 2022 - nature.com
Multiple sequence alignments are widely used to infer evolutionary relationships, enabling
inferences of structure, function, and phylogeny. Standard practice is to construct one …
inferences of structure, function, and phylogeny. Standard practice is to construct one …
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS …
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS …
Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …
genomes that enable the infection to persist despite challenges presented by host cells …
Origins and evolution of the global RNA virome
Viruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in
animals and plants. The recent advances of metaviromics prompted us to perform a detailed …
animals and plants. The recent advances of metaviromics prompted us to perform a detailed …
The nonstructural proteins directing coronavirus RNA synthesis and processing
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …