Coumarin and benzimidazole are privileged structures in medicinal chemistry and are
widely used in drug discovery and development due to their vast biological properties. The …

Drug development for neurodegenerative diseases (ND s) is foremost task for the medicinal
chemists in the 21st century. Coumarins are exemplary of an assorted and aptitudinally …

Natural coumarins and their derivatives isolated from various plants or microorganisms have
inherent antioxidant, antibacterial, antifungal, antiviral and anticancer properties among …

Cancer is one of the deadliest diseases nowadays and is a great topic for research as the
challenging task is to develop new entities with selectivity towards cancerous cells …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans,
and a current and promising inhibition target for the development of new chemosensitizing …

Cancer is the second life-threatening disease worldwide, and it resulted in around 9.6
million deaths globally in 2018. The multidrug-resistant cancers and non-selectivity create …

The pH sensing properties of five (four new) small-molecule fluorescent “turn-on” pH probes
based on 3-amino-and 3-dimethylamino-coumarin skeleton were investigated. Protonation …

Background: Inflammation substantially contributes to the development and progression of
malignancies. cancer-related inflammation, has been proposed to promote tumor …

Helicobacter pylori (H. pylori) is a microaerophilic gastric pathogen and a major contributor
to chronic atrophic gastritis, peptic ulcer, and gastric malignancies. The increasing …

Regulation of pH plays an essential role in orchestrating the delicate cellular machinery
responsible for life as we know it. Its abnormal values are indicative of aberrant cellular …