Therapeutic and responsive release mechanisms of polymer drug conjugates with diverse polymer skeletons

W Zhao, K Sun, J Yan, Y Sun, D Wei - Nano Today, 2024 - Elsevier
Polymer-drug conjugates (PDCs) have emerged as an advanced strategy in the drug
delivery. The conjugation of therapeutic or diagnostic agents to polymers, such as …

Robust Natural Light-Absorbable and-Degradable AIE Photosensitizers for Fluorescence Labeling and Efficient Photodynamic Eradication of Algal Pollutants

Q Yu, B Xu, J Geng, LH Xiong, Q Zhang… - ACS Applied Bio …, 2024 - ACS Publications
Current water pollution caused by the excessive proliferation of harmful algae urges green
methods that can efficiently utilize natural light to treat algal pollution. Herein, a series of …

Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation

A Thakur, YH Chu, NV Rao, J Mathew… - European Journal of …, 2024 - Elsevier
Careful recruitment of the components of the HDAC inhibitory template culminated in
veliparib-based anilide 8 that elicited remarkable cell growth inhibitory effects against HL-60 …

Tumor microenvironment-responsive self-assembling polymeric prodrug-based nanomaterials for cancer therapy

P Rani, JU Rahim, S Patra, R Gupta, M Gulati… - Journal of Drug Delivery …, 2024 - Elsevier
Prodrug approach, involving the chemical modification of an active moiety, is one of the
clinically proven strategies to overcome the unfavorable physicochemical and …

Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species

AP Mishra, R Kumar, S Harilal, M Nigam… - Naunyn-Schmiedeberg's …, 2024 - Springer
Advancements in therapeutic strategies and combinatorial approaches for cancer
management have led to the majority of cancers in the initial stages to be regarded as …

Engineered 1, 6-heptadiynes based polymeric prodrug system for anticancer drug delivery

P Kumar, D Patra, R Halder… - … Science, Part A, 2024 - Taylor & Francis
Diacetylene moiety, DIOL was functionalized to chemotherapeutic drug, chlorambucil and
water-soluble moiety poly (ethylene glycol) to get our macromonomer MPDC. MPDC was …