Evidence of disturbed insulin signaling in animal models of Alzheimer's disease

SS Alves, G Servilha-Menezes, L Rossi… - Neuroscience & …, 2023 - Elsevier
Since glucose reuptake by neurons is mostly independent of insulin, it has been an
intriguing question whether insulin has or not any roles in the brain. Consequently, the …

A complex systems view on the current hypotheses of epilepsy pharmacoresistance

G Servilha‐Menezes, N Garcia‐Cairasco - Epilepsia Open, 2022 - Wiley Online Library
Drug‐resistant epilepsy remains to this day as a highly prevalent condition affecting around
one‐third of patients with epilepsy, despite all the research and the development of several …

[HTML][HTML] Blueberry supplementation in midlife for dementia risk reduction

R Krikorian, MR Skelton, SS Summer, MD Shidler… - Nutrients, 2022 - mdpi.com
Late-life dementia typically develops over a period of many years beginning in midlife.
Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk …

Analyzing alternative splicing in Alzheimer's disease postmortem brain: a cell-level perspective

ME Farhadieh, K Ghaedi - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with no effective cure that attacks
the brain's cells resulting in memory loss and changes in behavior and language skills …

Evolving therapeutic interventions for the management and treatment of Alzheimer's disease

F Ahmad, A Karan, R Sharma, NS Sharma… - Ageing research …, 2024 - Elsevier
Alzheimer's Disease (AD) patients experience diverse symptoms, including memory loss,
cognitive impairment, behavioral abnormalities, mood changes, and mental issues. The …

Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT …

Y Su, N Liu, R Sun, J Ma, Z Li, P Wang, H Ma… - Frontiers in …, 2023 - frontiersin.org
Radix Rehmanniae Praeparata (RRP, Shu Dihuang in Cinese) is widely used as primal
medicine in Chinese herbal formula for the treatment of Alzheimer's disease (AD). However …

From attention-deficit hyperactivity disorder to sporadic Alzheimer's disease—Wnt/mTOR pathways hypothesis

E Grünblatt, J Homolak, A Babic Perhoc… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disorder with the majority
of patients classified as sporadic AD (sAD), in which etiopathogenesis remains unresolved …

Dimethyl fumarate alleviates adult neurogenesis disruption in hippocampus and olfactory bulb and spatial cognitive deficits induced by intracerebroventricular …

E Kurowska-Rucińska, J Ruciński, D Myślińska… - International Journal of …, 2022 - mdpi.com
The disorder of adult neurogenesis is considered an important mechanism underlying the
learning and memory impairment observed in Alzheimer's disease (AD). The sporadic …

Metabolic disturbances induced by sleep restriction as potential triggers for Alzheimer's disease

JE García-Aviles, R Méndez-Hernández… - Frontiers in Integrative …, 2021 - frontiersin.org
Sleep has a major role in learning, memory consolidation, and metabolic function. Although
it is known that sleep restriction increases the accumulation of amyloid β peptide (Aβ) and …

Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-Galactose

J Homolak, K Varvaras, V Sciacca, A Babic Perhoc… - ACS …, 2024 - ACS Publications
Recent evidence suggests that the gut plays a vital role in the development and progression
of Alzheimer's disease (AD) by triggering systemic inflammation and oxidative stress. The …