Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

This tutorial review surveys the latest achievements in the use of nanoparticles to detect
cancer biomarkers and cancer cells with a focus on optical and electrochemical techniques …

Protein solubility is a problem for many protein chemists, including structural biologists and
developers of protein pharmaceuticals. Knowledge about how intrinsic factors influence …

The early diagnosis of cancer can significantly improve patient survival rates. Colorimetric
methods for real-time naked-eye detection have aroused growing interest owing to their low …

Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

As important biomarkers for prostate cancer, total prostate specific antigen (tPSA) and free
prostate specific antigen (fPSA) levels in serum play essential roles in early diagnosis. In this …

Electrochemical immunosensors (EIs) for the determination of disease biomarkers has
attracted a wide interest due to its high sensitivity, low cost, and possible integration in …

Rapid progresses in nanotechnology fields have led us to use a number of advanced
nanomaterials (NMs) for engineering smart multifunctional nanoparticles …

The function of the lower urinary tract is basically storage of urine in the bladder and the at-
will periodic evacuation of the stored urine. Urinary incontinence is one of the most common …

Kallikreins are a family of serine proteases with a range of tissue-specific and essential
proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 …