Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …

Several important and previously unrecognized roles for the neurotransmitter glutamate in
the biology of primary brain tumors have recently been elucidated. Glutamate is produced …

Learning and memory depend on persistent changes in synaptic strength that require
neuronal gene expression. An unresolved question concerns the mechanisms by which …

Neurotransmitter receptors are responsible for the transfer of information across the
synapse. While ionotropic receptors form ion channels and mediate rapid membrane …

It has been widely accepted that neurogenesis continues throughout life. Neural stem cells
can be found in the ventricular zone of the embryonic and in restricted regions of the adult …

The GluD1 and GluD2 receptors form the GluD ionotropic glutamate receptor (iGluR)
subfamily. Without known endogenous ligands, they have long been referred to as …

Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of
synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to …

Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are
ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many …

MAPK/Erk is a protein kinase activated by neurotrophic factors involved in synapse
formation and plasticity, which acts at both the nuclear and cytoplasmic level. Synapsin …